换一批
换一批Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
第一作者：
Mariana,Puntel
第一单位：
Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5689, USA.
作者：
主题词
腺病毒科(Adenoviridae);动物(Animals);脑肿瘤(Brain Neoplasms);临床试验, Ⅰ期(主题)(Clinical Trials, Phase I as Topic);细胞毒素类(Cytotoxins);药物评价, 临床前(Drug Evaluation, Preclinical);药物疗法, 联合(Drug Therapy, Combination);遗传载体(Genetic Vectors);胶质母细胞瘤(Glioblastoma);人类(Humans);免疫法(Immunization);男(雄)性(Male);大鼠(Rats);大鼠, 近交Lew(Rats, Inbred Lew);组织分布(Tissue Distribution);治疗结果(Treatment Outcome)
DOI
10.1016/j.taap.2013.02.001
PMID
23403069
发布时间
2024-03-18
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