换一批Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition.
第一作者：
Kathleen B,Smith
第一单位：
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA.
作者：
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);动物(Animals);细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation);减量调节(Down-Regulation);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);脂类代谢(Lipid Metabolism);脂肪肉瘤(Liposarcoma);男(雄)性(Male);小鼠(Mice);中年人(Middle Aged);肿瘤侵润(Neoplasm Invasiveness);PTEN磷酸水解酶(PTEN Phosphohydrolase);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);蛋白激酶抑制剂(Protein Kinase Inhibitors);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1016/j.ajpath.2013.01.002
PMID
23416162
发布时间
2022-03-31
基金项目
P50 CA086306/CA/NCI NIH HHS/United States
T32 CA009056/CA/NCI NIH HHS/United States
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