换一批
换一批Asperolide A, a marine-derived tetranorditerpenoid, induces G2/M arrest in human NCI-H460 lung carcinoma cells, is mediated by p53-p21 stabilization and modulated by Ras/Raf/MEK/ERK signaling pathway.
作者：
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);癌(Carcinoma);细胞系, 肿瘤(Cell Line, Tumor);顺铂(Cisplatin);DNA结合蛋白质类(DNA-Binding Proteins);二萜类(Diterpenes);细胞外信号调节MAP激酶类(Extracellular Signal-Regulated MAP Kinases);基因表达调控(Gene Expression Regulation);人类(Humans);免疫抑制剂(Immunosuppressive Agents);肺肿瘤(Lung Neoplasms);MAP激酶激酶激酶类(MAP Kinase Kinase Kinases);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);分子结构(Molecular Structure);肿瘤, 实验性(Neoplasms, Experimental);信号传导(Signal Transduction);转录因子(Transcription Factors);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);raf激酶类(raf Kinases);ras蛋白质类(ras Proteins)
DOI
10.3390/md11020316
PMID
23434831
发布时间
2021-10-21
- 浏览114
Marine drugs
316-31页
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