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首页> The Journal of steroid biochemistry and molecular biology> Steroidogenesis in the skin: implications for local immune functions.

Steroidogenesis in the skin: implications for local immune functions.

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作者： Andrzej,Slominski ^[1] ; Blazej,Zbytek ; Georgios,Nikolakis ; Pulak R,Manna ; Cezary,Skobowiat ; Michal,Zmijewski ; Wei,Li ; Zorica,Janjetovic ; Arnold,Postlethwaite ; Christos C,Zouboulis ; Robert C,Tuckey

作者单位： Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: aslominski@uthsc.edu. ^[1]

关键词 11-hydroxysteroiddehydrogenase type 1 11-hydroxysteroiddehydrogenase type 2 11β-hydroxylase type 1 11β-hydroxylase type 2 17β-HSD 17β-hydroxysteroid dehydrogenase 21-hydroxylase 3α-HSD 3α-hydroxysteroid dehydrogenase 3β-HSD 3β-hydroxysteroid dehydrogenase 5α-reductase 5αR ACTH Androgen CD CRH CYP11A1 CYP11A1 or P450scc CYP11B1 CYP11B2 CYP17A1 or P450c17 CYP21 DAX-1 DHEA DHT DOC DPCs E1 E2 ECM ERE ERR Estrogen GM-CSF GR Glucocorticoids HF HPA HS HSD11B1 or 11-HSD 1 HSD11B2 or 11-HSD 2 INF IRSKS LE MHC MR NFkB NHEKs ORSKs POMC SF-1 SP SSc Skin endocrine system Skin immune system StAR T T helper TGFβ Th UVR adrenocorticotropic hormone cAMP-dependent protein kinase A cAMP/PKA cluster of differentiation corticotrophin releasing hormone cytochrome P450 17α-hydroxylase/17,20-lyase cytochrome P450 side-chain cleavage enzyme dehydroepiandrosterone deoxycorticosterone dermal papilla cells dihydrotestosterone dosage-sensitive sex-reversal-adrenal hypoplasia congenital critical region on the x-chromosome, gene 1 estradiol estrogen response element estrogen-related receptor estrone extracellular matrix glucocorticoid receptor granulocyte-macrophage colony-stimulating factor hair follicle hidradenitis suppurativa/acne inversa hypothalamus–pituitary–adrenal gland inner root sheath keratinocytes interferon lupus erythematosus major histocompatibility complex mineralocorticoid receptor normal human epidermal keratinocytes nuclear factor kappa-light-chain-enhancer of activated B cells outer root sheath keratinocytes proopiomelanocortin steroidogenic acute regulatory protein steroidogenic factor 1 substance P systemic sclerosis testosterone transforming growth factor β ultraviolet radiation

主题词人类(Humans);炎症(Inflammation);皮肤(Skin);甾类(Steroids)

DOI 10.1016/j.jsbmb.2013.02.006

PMID 23435015

发布时间 2021-10-21

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The Journal of steroid biochemistry and molecular biology

107-23页

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