The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS).

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作者： Inga,Tluczkiewicz ^[1] ; Monika,Batke ; Dinant,Kroese ; Harrie,Buist ; Tom,Aldenberg ; Eduard,Pauné ; Helvi,Grimm ; Ralph,Kühne ; Gerrit,Schüürmann ; Inge,Mangelsdorf ; Sylvia E,Escher

作者单位： Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs Straße 1, 30625 Hannover, Germany; Institute for Organic Chemistry, Technical University Bergakademie Freiberg, Leipziger Str. 29, 09596 Freiberg, Germany. Electronic address: inga.tluczkiewicz@item.fraunhofer.de. ^[1]

关键词 3R principle Alternative ITS Integrated Testing Strategy Non-testing method OSIRIS Repeated-dose Risk Assessment TTC Weighting

主题词动物(Animals);危害物质(Hazardous Substances);危险性评估(Risk Assessment);软件(Software);毒性试验(Toxicity Tests)

DOI 10.1016/j.yrtph.2013.02.004

PMID 23439429

发布时间 2013-11-01

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