换一批Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.
第一作者：
Michael C,Van Zandt
第一单位：
Institutes for Pharmaceutical Discovery , LLC, 23 Business Park Drive, Branford, Connecticut 06405, USA. mvzandt@snet.net
作者：
医学主题词
氨基酸类(Amino Acids);动物(Animals);精氨酸酶(Arginase);硼化合物(Boron Compounds);CHO细胞(CHO Cells);己酸盐类(Caproates);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);药物发现(Drug Discovery);酶抑制剂(Enzyme Inhibitors);人类(Humans);男(雄)性(Male);模型, 分子(Models, Molecular);心肌再灌注损伤(Myocardial Reperfusion Injury);蛋白质构象(Protein Conformation);大鼠(Rats);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm400014c
PMID
23472952
发布时间
2021-04-05
- 浏览79
Journal of medicinal chemistry
2568-80页
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