The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohort.
第一作者:
D T O,Mainardi-Novo
第一单位:
Laboratório de Investigação Médica 18 (LIM-18), Hospital das Clínicas-Faculdade de Medicina da Universidade de São Paulo, Unidade de Diabetes, São Paulo, Brazil.
作者:
主题词
等位基因(Alleles);自身抗体(Autoantibodies);巴西(Brazil);病例对照研究(Case-Control Studies);糖尿病, 1型(Diabetes Mellitus, Type 1);女(雌)性(Female);基因表达(Gene Expression);基因频率(Gene Frequency);疾病遗传易感性(Genetic Predisposition to Disease);谷氨酸脱羧酶(Glutamate Decarboxylase);HLA-DR3抗原(HLA-DR3 Antigen);HLA-DR4抗原(HLA-DR4 Antigen);人类(Humans);白细胞介素类(Interleukins);男(雄)性(Male);启动区, 遗传(Promoter Regions, Genetic);蛋白质酪氨酸磷酸酶, 非受体22型(Protein Tyrosine Phosphatase, Non-Receptor Type 22);危险(Risk);序列分析, DNA(Sequence Analysis, DNA)
DOI
10.1111/cei.12030
PMID
23480181
发布时间
2022-12-07
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