换一批A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits.
第一作者：
David M,Feliciano
第一单位：
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
作者：
关键词
4E-BP1AutismCNSCSFCreERT2DendriteDifferentiationEEEGEpilepsyFCDsFMR1FMRPFMRP geneFXSGAPGFAPGTPase activating proteinIUELOHLTDLTPLVMRIMental retardationMigrationNeurogenesisPPP2AProgenitor cellRGCsRas homolog enriched in brainRhebS6K1SEGASENSEZSeizuresSpineStem cellSynI-CreSynapsin I promoter-driven CreTSCTSC gene 1 or gene 2TSC1 or TSC2Tsc1(fl/fl)Tsc1(fl/mut)Tsc1(wt/mut)TuberTuberous sclerosis complexcentral nervous systemcerebral spinal fluideIF4E-binding protein 1electroencephalographyembryonic dayflfloxedfloxed Tsc1 alleles (transgenic mice)floxed and mutant Tsc1 allelesfocal cortical dysplasiasfragile X mental retardation proteinfragile X syndromeglial fibrillary acidic proteinhgfaphuman gfapin utero electroporationinducible Crelateral ventriclelong-term depressionlong-term potentiationloss of heterozygositymGluR-LTDmTORmTOR complex 1 or 2mTORC1 or mTORC2magnetic resonance imagingmammalian Target of Rapamycinmetabotropic glutamate receptor class I long term depressionmgfapmouse gfapp70 S6 Kinase 1postnatal dayprotein phosphatase 2Aretinal ganglion cellssubependymal giant cell astrocytomasubependymal nodulessubependymal zonetuberous sclerosis complexwildtype and mutant Tsc1 alleles
医学主题词
动物(Animals);中枢神经系统(Central Nervous System);认知障碍(Cognition Disorders);疾病模型, 动物(Disease Models, Animal);癫痫(Epilepsy);人类(Humans);小鼠(Mice);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);结节性硬化症(Tuberous Sclerosis)
DOI
10.1016/j.ijdevneu.2013.02.008
PMID
23485365
发布时间
2022-03-09
- 浏览67
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
