High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan.
作者:
主题词
细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);细胞周期蛋白依赖激酶2(Cyclin-Dependent Kinase 2);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);减量调节(Down-Regulation);人类(Humans);微RNAs(MicroRNAs);NFI转录因子类(NFI Transcription Factors);新生血管化, 生理性(Neovascularization, Physiologic);RNA干扰(RNA Interference);RNA, 小分子干扰(RNA, Small Interfering);转染(Transfection);增量调节(Up-Regulation);cdc25磷酸酶类(cdc25 Phosphatases)
DOI
10.1111/acel.12069
PMID
23496142
发布时间
2022-04-08
- 浏览6

Aging cell
446-58页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文