换一批
换一批An approach for integrating toxicogenomic data in risk assessment: the dibutyl phthalate case study.
作者：
关键词
3 beta-hydroxysteroid dehydrogenase/delta-5–delta-4 isomerase type IIADMEAGDALDH2ARBBDR modelCNPsCYP2D6Cyp11a1/P450sccCyp17a1Cyp2b1Cyp3a1DBPDEGDEHPD–REDCEndocrine disrupting chemicalGOHsd3bIRISInsl3Integrated Risk Information SystemMBPMOAMale developmentNIEHSNOAELNational Institute of Environmental Health SciencesPBPK modelingPhthalatesRT-PCRRisk assessmentSDSTARScarb1Science to Achieve ResultsSprague–DawleyStarTTDTDSTGxTKTestosteroneToxicogenomicU.S. Environmental Protection AgencyUDP glucuronosyltransferase 2B1UF(H)US EPAUgt2b1WOEabsorption, distribution, metabolism, and excretionaldehyde dehydrogenase-2androgen receptoranogenital distancebiologically based dose–response modelcopy number polymorphismscytochrome P450 2D6cytochrome P450, family 11, subfamily a, polypeptide 1cytochrome P450, family 17, subfamily a, polypeptide 1cytochrome P450, family 2, subfamily b, polypeptide 1cytochrome P450, family 3, subfamily a, polypeptide 1di-(2-ethylhexyl) phthalatedibutyl phthalatedifferentially-expressed genedose–responseendocrine disrupting chemicalgene ontologyinsulin-like 3mode of actionmonobutyl phthalateno observed adverse effect levelphysiologically based pharmacokinetic modelingreverse transcription-polymerase chain reactionscavenger receptor class B, member 1steroidogenic acute regulatory proteintesticular dysgenesis syndrometestosteronetoxicodynamicstoxicogenomictoxicokineticsuncertainty factor for uncertainty in extrapolating animal data to humans (i.e., interspecies uncertainty) (http://www.epa.gov/IRIS/)weight-of-evidence
主题词
动物(Animals);邻苯甲二酸二丁酯(Dibutyl Phthalate);环境污染物(Environmental Pollutants);基因表达调控(Gene Expression Regulation);基因组学(Genomics);人类(Humans);成形剂(Plasticizers);危险性评估(Risk Assessment)
DOI
10.1016/j.taap.2013.03.013
PMID
23537663
发布时间
2013-11-21
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