换一批
换一批A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure.
作者：
关键词
16223939.2DCMDdDsEEDWTEFELISAESWTE′HGFLVONO1301SRPCRPLGASDF-1VEGFdilated cardiomyopathyearly diastolic velocity of the mitral annulusearly transmitral filling waveejection fractionend-diastolic left ventricular dimensionend-diastolic wall thicknessend-systolic left ventricular dimensionend-systolic wall thicknessenzyme-linked immunosorbent assayhepatocyte growth factorleft ventricular (ventricle)mRNAmessenger RNApolylactic and glycolic acid polymerpolymerase chain reactionslow releasing form of ONO1301stromal-derived factor-1vascular endothelial growth factor
主题词
动物(Animals);心脏起搏, 人工(Cardiac Pacing, Artificial);心肌病, 扩张型(Cardiomyopathy, Dilated);心血管药物(Cardiovascular Agents);细胞系(Cell Line);化学, 药物(Chemistry, Pharmaceutical);细胞因子类(Cytokines);迟效制剂(Delayed-Action Preparations);疾病模型, 动物(Disease Models, Animal);狗(Dogs);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物载体(Drug Carriers);超声心动描记术, 多普勒(Echocardiography, Doppler);成纤维细胞(Fibroblasts);心力衰竭(Heart Failure);人类(Humans);注射, 肌肉内(Injections, Intramuscular);乳酸(Lactic Acid);显微镜检查, 电子(Microscopy, Electron);线粒体, 心脏(Mitochondria, Heart);心肌(Myocardium);聚乙醇酸(Polyglycolic Acid);吡啶类(Pyridines);RNA, 信使(RNA, Messenger);功能恢复(Recovery of Function);每搏输出量(Stroke Volume);时间因素(Time Factors);增量调节(Up-Regulation);心室功能, 左(Ventricular Function, Left);心室重构(Ventricular Remodeling)
DOI
10.1016/j.jtcvs.2012.10.003
PMID
23541854
发布时间
2018-12-02
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