Repression of Zeb1 and hypoxia cause sequential mesenchymal-to-epithelial transition and induction of aid, Oct4, and Dnmt1, leading to immortalization and multipotential reprogramming of fibroblasts in spheres.
第一作者:
Yongqing,Liu
第一单位:
James Graham Brown Cancer Center, Louisville, KY, USA.
作者:
主题词
动物(Animals);细胞分化(Cell Differentiation);细胞低氧(Cell Hypoxia);细胞, 培养的(Cells, Cultured);胞苷脱氨酶(Cytidine Deaminase);DNA甲基化(DNA Methylation);上皮-间质转化(Epithelial-Mesenchymal Transition);成纤维细胞(Fibroblasts);基因敲低技术(Gene Knockdown Techniques);同源盒结构域蛋白质类(Homeodomain Proteins);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);Kruppel样转录因子类(Kruppel-Like Transcription Factors);小鼠(Mice);多能干细胞(Multipotent Stem Cells);八聚体转录因子3(Octamer Transcription Factor-3);启动区, 遗传(Promoter Regions, Genetic);干细胞(Stem Cells)
DOI
10.1002/stem.1382
PMID
23554223
发布时间
2024-06-20
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Stem cells (Dayton, Ohio)
1350-62页
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