In vitro microarray analysis identifies genes in acute-phase response pathways that are down-regulated in the liver of chicken embryos exposed in ovo to PFUdA.
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关键词
APRCEHChickenDEDMSOFDRGSHGene-expressionHNF4AHepatocyteIPAIngenuity Pathway AnalysisMode of actionPFCPFCAPFDSPFNAPFOAPFOSPFUdAPPARαPPARγPerfluorooctane sulfonatePerfluoroundecanoic acidTP53a2macute-phase responsealpha-2-macroglobulincarboxypeptidase B2cdo1chicken embryonic hepatocytescpb2cysteine dioxygenase type Idifferentially expresseddimethyl sulfoxidef2false discovery ratefgafggfibrinogen alphafibrinogen gammaglutathioneglutathione-S-transferase alpha 3glutathione-S-transferase alpha 4glutathione-S-transferase omega 1gsta3gsta4gsto1hepatocyte nuclear factor 4 alphainterferon stimulated gene 12 protein-like 2isg12-2lbfabpliver basic fatty acid binding proteinmgst1microsomal glutathione-S-transferase 1perfluoroalkyl compoundperfluorocarboxylic acidperfluorodecane sulfonateperfluorononanoic acidperfluorooctane sulfonateperfluorooctanoic acidperfluoroundecanoic acidperosixome proliferator-activated receptor alphaperoxisome proliferator-activated receptor gammaplasminogenplgproCprotein Cthrombin (coagulation factor II)tumor protein 53
主题词
急相反应(Acute-Phase Reaction);动物(Animals);鸟蛋白质类(Avian Proteins);细胞, 培养的(Cells, Cultured);鸡胚(Chick Embryo);减量调节(Down-Regulation);环境污染物(Environmental Pollutants);脂肪酸类(Fatty Acids);氟碳化合物(Fluorocarbons);基因表达谱(Gene Expression Profiling);肝细胞(Hepatocytes);肝(Liver);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis)
DOI
10.1016/j.tiv.2013.04.003
PMID
23602845
发布时间
2013-08-20
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Toxicology in vitro
1649-58页
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