Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.
作者:
主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);佐剂, 免疫(Adjuvants, Immunologic);动物(Animals);CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins);细胞分化(Cell Differentiation);索状因子(Cord Factors);炎性体(Inflammasomes);白细胞介素1β(Interleukin-1beta);外源凝集素类, C型(Lectins, C-Type);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);分枝杆菌属(Mycobacterium);髓样分化因子88(Myeloid Differentiation Factor 88);肽聚糖(Peptidoglycan);受体, 白细胞介素1(Receptors, Interleukin-1);受体, 白细胞介素18(Receptors, Interleukin-18);信号传导(Signal Transduction);Th17细胞(Th17 Cells);Toll样受体(Toll-Like Receptors)
DOI
10.4049/jimmunol.1203343
PMID
23630357
发布时间
2023-06-18
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