Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma.
第一作者:
Changju,Qu
第一单位:
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
作者:
主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);成年人(Adult);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞增殖(Cell Proliferation);细胞因子类(Cytokines);电泳迁移位移试验(Electrophoretic Mobility Shift Assay);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);鸟苷酸环化酶(Guanylate Cyclase);猬蛋白质类(Hedgehog Proteins);异源三聚体GTP结合蛋白质类(Heterotrimeric GTP-Binding Proteins);人类(Humans);I-κB激酶(I-kappa B Kinase);免疫酶技术(Immunoenzyme Techniques);免疫沉淀法(Immunoprecipitation);萤光素酶类(Luciferases);淋巴瘤, 大B细胞, 弥漫性(Lymphoma, Large B-Cell, Diffuse);NF-κB(NF-kappa B);肿瘤蛋白质类(Neoplasm Proteins);蛋白激酶C(Protein Kinase C);RNA, 信使(RNA, Messenger);RNA, 小分子干扰(RNA, Small Interfering);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);TNF受体相关因子6(TNF Receptor-Associated Factor 6);组织阵列分析(Tissue Array Analysis);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.1182/blood-2012-12-470153
PMID
23632891
发布时间
2021-10-21
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Blood
4718-28页
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