Enhanced immune response and protective effects of nano-chitosan-based DNA vaccine encoding T cell epitopes of Esat-6 and FL against Mycobacterium tuberculosis infection.
作者:
主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);抗原, 细菌(Antigens, Bacterial);细菌蛋白质类(Bacterial Proteins);细胞计数(Cell Count);细胞增殖(Cell Proliferation);壳聚糖(Chitosan);细胞因子类(Cytokines);表位, T淋巴细胞(Epitopes, T-Lymphocyte);女(雌)性(Female);GATA3转录因子(GATA3 Transcription Factor);基因表达调控(Gene Expression Regulation);免疫法(Immunization);干扰素γ(Interferon-gamma);配体(Ligands);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);分子序列数据(Molecular Sequence Data);结核分枝杆菌(Mycobacterium tuberculosis);纳米粒子(Nanoparticles);粒子大小(Particle Size);重组蛋白质类(Recombinant Proteins);脾(Spleen);T盒域蛋白质类(T-Box Domain Proteins);T淋巴细胞, 细胞毒性(T-Lymphocytes, Cytotoxic);转染(Transfection);结核(Tuberculosis);疫苗, DNA(Vaccines, DNA);fms样酪氨酸激酶3(fms-Like Tyrosine Kinase 3)
DOI
10.1371/journal.pone.0061135
PMID
23637790
发布时间
2024-05-08
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