Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1α (HP1α) with heterochromatin.
作者:
主题词
动物(Animals);COS细胞(COS Cells);细胞核(Cell Nucleus);染色体蛋白质类, 非组蛋白(Chromosomal Proteins, Non-Histone);异染色质(Heterochromatin);人类(Humans);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白质加工, 转译后(Protein Processing, Post-Translational);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);阻遏蛋白质类(Repressor Proteins);酪氨酸(Tyrosine);src族激酶类(src-Family Kinases)
DOI
10.1074/jbc.M112.437756
PMID
23645696
发布时间
2021-12-03
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