Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A.
作者:
主题词
动物(Animals);细胞系(Cell Line);雌激素受体α(Estrogen Receptor alpha);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);内环境稳定(Homeostasis);同工酶类(Isoenzymes);L-乳酸脱氢酶(L-Lactate Dehydrogenase);乳酸(Lactic Acid);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肌蛋白质类(Muscle Proteins);肌, 骨骼(Muscle, Skeletal);身体条件作用, 动物(Physical Conditioning, Animal);反式激活因子类(Trans-Activators);转录因子(Transcription Factors)
DOI
10.1073/pnas.1212976110
PMID
23650363
发布时间
2023-04-11
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