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Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.

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第一作者: Maddalena,Frau
第一单位: Department of Clinical and Experimental Medicine, Laboratory of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy.
作者单位: Department of Clinical and Experimental Medicine, Laboratory of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy. [1]
关键词 5-methyltetrahydrofolate homocysteine methyltransferase5’-Methylthioadenosine phosphorylase5′-MTA5′-methylthioadenosineAKTAMP activated protein kinaseAMPKAPAP-1APEX1ASHASOAUF1AUrich RNA binding factor 1B-cell cell/lymphoma 2BAKBAXBCL2BCL2 antagonist killerBCL2-associated x proteinBHMTCBSCDC2CDC28 protein kinase b1CSK1DNDUSP1EGR-1ERKEpigenetic regulationFASFOXM1GIGNMTGSHHCCHCC with better prognosisHCC with poorer prognosisHCCBHCCPHGFHIF-1αHepatocarcinogenesisHu antigen RHuRIKKJAKJUNJanus kinaseLDLLKB1MAFKMAPKMATMDDMDM2MTHF-HMTMethionine adenosyltransferaseMtapNASHNF-kBNOSODCPCNAPFK-2PHPHB1PI3KPIAS1PP2APRMT5PrognosisProgressionRAS guanyl releasing protein 3RASGRP3RBPROSS-adenosylhomocysteineS-adenosylmethionineS-phase kinase-associated protein 2SAHSAH hydroxylaseSAHHSAMSAM dacarboxylaseSKP2SLSP1STAT1SdcSignal transductionSmrSmsSpp1TNFαTSC1TSC2USP7Ubiquitin-specific-processing protease 7V-AKT murine thymoma viral oncogene homologV-JUN avian sarcoma virus 17 oncogene homologV-MAF avian musculoaponeurotic fibrosarcoma oncogene family, protein KV-MYB avian myeloblastosis viral oncogene homolog-like 2VLDLXIAPactivator protein-1alcoholic steatohepatitisantisense oligonucleotideapurinic/apyrimidinicbetaine-homocysteine methyltransferasec-Mybl2cell division cycle 2cystathionine β-synthasedual-specificity phosphatase 1dysplastic noduleearly growth response protein-1endonuclease redox effector APE1/REF-1/APEX1extracellular signal-regulated kinaseforkhead box M1Bgenomic instabilityglycine N-methyltransferasehamartinhepatocellular carcinomahepatocyte growth factorhypoxia-inducible factor 1, alpha subunitinhibitor of apoptosis, x-linkedinhibitor of kappa light chain gene enhancer in B cells, kinase oflow density lipoproteinsmRNA-binding proteinsmTORC2mammalian target of rapamycin complexmethionine adenosyltransferasemethyl deficient dietmitogen-activated protein kinasemouse double minute 2 homolognitric oxide synthasenon-alcoholic steatohepatitisnuclear factor kBornithine decarboxylasep90RSKpartial hepatectomyphosphatadylinositol 3-kinasephosphofructokinase 2prohibitin 1proliferating cell nuclear antigenprotein arginine methyltransferase 5protein inhibitor of activated STAT1protein phosphatase 2Areactive oxygen speciesreduced glutathioneribosomal protein S6 kinase polypeptide 2secreted phosphoprotein 1serine/threonine protein kinase 11signal transducer and activator of transcriptionspecificity protein 1spermidine synthasespermine synthasesurrounding livertuberintumor necrosis factor receptor superfamily, member 6tumor necrosis factor αvery low density lipoproteins
DOI 10.1016/j.jhep.2013.04.031
PMID 23665184
发布时间 2022-03-30
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Journal of hepatology

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