换一批Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.
第一作者：
Emilie,Collmann
第一单位：
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
作者：
关键词
2,4,6-Trinitrophenol2,4-DinitrophenolBMMCBone marrow–derived mast cellDNPFACSFluorescence-activated cell sortingG protein–coupled receptorGPCRHUVECHalf-maximal inhibitory concentrationHuman umbilical vein endothelial cellIC(50)IMDMIscove modified Dulbecco mediumMAPKMast cellsMitogen-activated protein kinasePCAPI3KPKB/AktPassive cutaneous anaphylaxisPhosphatidylinositolPhosphoinositide 3-kinasePhosphorylated PKBProtein kinase BPtdInsSCFSDF-1αStem cell factorStromal cell–derived factor 1αTNPVCAM-1VLAVascular cell adhesion molecule 1Very late antigenallergyanaphylaxisinflammationmigrationpPKBphosphoinositide 3-kinaserecruitment
医学主题词
过敏反应(Anaphylaxis);动物(Animals);抗变态反应药(Anti-Allergic Agents);细胞脱颗粒(Cell Degranulation);细胞运动(Cell Movement);Ib类磷脂酰肌醇3-激酶(Class Ib Phosphatidylinositol 3-Kinase);内皮细胞(Endothelial Cells);酶抑制剂(Enzyme Inhibitors);人类(Humans);超敏反应(Hypersensitivity);肥大细胞(Mast Cells);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases)
DOI
10.1016/j.jaci.2013.03.008
PMID
23683463
发布时间
2019-12-10
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