The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling.

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作者： Jin A,Cho ^[1] ; Ann-Hwee,Lee ^[2] ; Barbara,Platzer ^[1] ; Benedict C S,Cross ^[3] ; Brooke M,Gardner ^[4] ; Heidi,De Luca ^[1] ; Phi,Luong ^[1] ; Heather P,Harding ^[3] ; Laurie H,Glimcher ^[5] ; Peter,Walter ^[6] ; Edda,Fiebiger ^[7] ; David,Ron ^[3] ; Jonathan C,Kagan ^[7] ; Wayne I,Lencer ^[8]

作者单位： Department of Medicine, Division of GI Cell Biology, Boston Children's Hospital, Boston, MA 02115, USA. ^[1] Harvard Digestive Diseases Center, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA. ^[2] University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK. ^[3] Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2517, USA. ^[4] Harvard Digestive Diseases Center, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. ^[5] Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2517, USA; Howard Hughes Medical Institute. ^[6] Department of Medicine, Division of GI Cell Biology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Digestive Diseases Center, Harvard Medical School, Boston, MA 02115, USA. ^[7] Department of Medicine, Division of GI Cell Biology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Digestive Diseases Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address: wayne.lencer@childrens.harvard.edu. ^[8]