换一批
换一批Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
第一作者：
Bahar,Tunctan
第一单位：
Department of Pharmacology, Faculty of Pharmacy, Mersin University, 33169 Mersin, Turkey. tunctanb@yahoo.com
作者：
关键词
1,3-PBIT20-HEDE20-HETE20-hydroxyeicosa-6(Z),15(Z)-dienoic acid20-hydroxyeicosatetraenoic acid5,14-HEDGEAACOXCOX-2CYPCYP4A1EETELISAERKEndotoxinHRHypotensionIKKILIκBIκB kinaseLPSMAPMAPKMEKN-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycineNADPHNF-κBNOPGPKGRT-PCRTNFVASParachidonic acidcDNAcGMPcomplementary deoxyribonucleic acidcyclic guanosine monophosphatecyclooxygenasecyctochrome P450eNOSendothelial nitric oxide synthaseenzyme-linked immunosorbent assayepoxyeicosatrienoic acidextracellular signal-regulated kinasegp91(phox)/NOX2heart rateheat shock proteinhspi.p.iNOSiNOS/sGC/PKG pathwayinducible nitric oxide synthaseinhibitor of κBinterleukinintraperitoneallylipopolysaccharidemRNAmean arterial pressuremessenger ribonucleic acidmitogen-activated protein kinasemitogen-activated protein kinase kinase 1nicotinamide adenine dinucleotide phosphatenitric oxidenuclear factor-κBp-VASPphenylene-1,3-bis(ethane-2-isothiourea) dihydrobromidephosphorylated vasodilator stimulated phosphoproteinprostaglandinprotein kinase Greverse transcription-polymerase chain reactions.c.sEHsGCsoluble epoxide hydrolasesoluble guanylyl cyclasesubcutaneouslytumor necrosis factorvasodilator stimulated phosphoprotein
主题词
动物(Animals);细胞黏附分子(Cell Adhesion Molecules);环GMP依赖性蛋白激酶类(Cyclic GMP-Dependent Protein Kinases);环氧化酶2(Cyclooxygenase 2);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);疾病模型, 动物(Disease Models, Animal);鸟苷酸环化酶(Guanylate Cyclase);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);羟基花生四烯酸类(Hydroxyeicosatetraenoic Acids);脂肽类(Lipopeptides);脂多糖类(Lipopolysaccharides);男(雄)性(Male);膜糖蛋白类(Membrane Glycoproteins);微丝蛋白质类(Microfilament Proteins);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);器官特异性(Organ Specificity);过氧亚硝酸(Peroxynitrous Acid);磷蛋白类(Phosphoproteins);预防和防护用药(Protective Agents);RNA, 信使(RNA, Messenger);随机分配(Random Allocation);大鼠(Rats);大鼠, Wistar(Rats, Wistar);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);休克, 脓毒性(Shock, Septic);信号传导(Signal Transduction)
DOI
10.1016/j.niox.2013.05.001
PMID
23684565
发布时间
2025-01-03
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Nitric oxide
18-41页
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