换一批
换一批In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models.
第一作者：
M T,Pulido-Rios
第一单位：
Department of Pharmacology, Theravance, Inc., South San Francisco, CA 94080, USA. tpulidorios@theravance.com
作者：
主题词
乙酰胆碱(Acetylcholine);投药, 吸入(Administration, Inhalation);动物(Animals);苯甲酰胺类(Benzamides);支气管收缩(Bronchoconstriction);支气管扩张药(Bronchodilator Agents);氨甲酸酯类(Carbamates);狗(Dogs);剂量效应关系, 药物(Dose-Response Relationship, Drug);格隆溴铵(Glycopyrrolate);肺(Lung);男(雄)性(Male);氯醋甲胆碱(Methacholine Chloride);毒蕈碱拮抗剂(Muscarinic Antagonists);毛果芸香碱(Pilocarpine);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 毒蕈碱M1(Receptor, Muscarinic M1);受体, 毒蕈碱M3(Receptor, Muscarinic M3);唾液分泌(Salivation);东莨菪碱衍生物(Scopolamine Derivatives)
DOI
10.1124/jpet.113.203554
PMID
23685545
发布时间
2022-04-08
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