换一批Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
第一作者：
Satoshi,Inoue
第一单位：
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada.
作者：
医学主题词
9,10-二甲基-1,2-苯并蒽(9,10-Dimethyl-1,2-benzanthracene);动物(Animals);细胞转化, 肿瘤(Cell Transformation, Neoplastic);细胞, 培养的(Cells, Cultured);周期素依赖激酶抑制剂p15(Cyclin-Dependent Kinase Inhibitor p15);周期素依赖激酶抑制剂p16(Cyclin-Dependent Kinase Inhibitor p16);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);减量调节(Down-Regulation);女(雌)性(Female);基因, ras(Genes, ras);角蛋白细胞(Keratinocytes);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);核蛋白质类(Nuclear Proteins);癌基因蛋白质p21(ras)(Oncogene Protein p21(ras));活化STAT的蛋白抑制物(Protein Inhibitors of Activated STAT);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);信号传导(Signal Transduction);皮肤肿瘤(Skin Neoplasms);十四酰佛波乙酯(Tetradecanoylphorbol Acetate);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);肿瘤抑制蛋白质类(Tumor Suppressor Proteins);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1101/gad.214577.113
PMID
23699408
发布时间
2025-05-29
- 浏览152
Genes & development
1101-14页
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