换一批Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties.
第一作者：
Fabien,Lecaille
第一单位：
Université François Rabelais, Tours, France.
作者：
关键词
1,2-dipalmitoyl-sn-glycero-3-phosphocholine1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol3-NO(2)-Tyr3-nitro-tyrosine4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride7-amino-4-methyl coumarinAEBSFAMCAbzAntimicrobial proteinBALFBCACA-074CFCatCollectinCysteine proteaseCystic fibrosisDL-dithiothreitolDPPCDPPGDTTE-64FRETHNEL-3-carboxy-trans-2.3-epoxypropionyl-leucylamido-(4-guanidino) butaneLungMMTsMu-Leu-Hph-VSPhN-(l-3-trans-propylcarbamoyloxirane-2-carbonyl)-l-isoleucyl-l-prolineNSPP. aeruginosa-negativePMAPMSFProteolysisPs+Ps-Pseudomonas aeruginosa-positiveRTSP-ATBSZbenzyloxycarbonylbicinchoninic acidbroncho-alveolar lavage fluidcathepsincystic fibrosisfluorescence resonance energy transferhuman neutrophil elastasemethylmethanethiosulfonatemorpholine urea-leucyl-homophenylalanyl-(vinylsulfonyl)benzeneneutrophil serine proteaseortho-aminobenzoic acidphenylmethylsulfonyl fluoridephorbol 12-myristate 13-acetateroom temperaturesurfactant protein Atris buffer saline
主题词
凝集反应(Agglutination);氨基酸序列(Amino Acid Sequence);动物(Animals);抗菌药(Anti-Bacterial Agents);钙(Calcium);组织蛋白酶类(Cathepsins);牛(Cattle);囊性纤维化(Cystic Fibrosis);大肠杆菌(Escherichia coli);人类(Humans);水解作用(Hydrolysis);肺(Lung);分子序列数据(Molecular Sequence Data);蛋白质结构, 三级(Protein Structure, Tertiary);铜绿假单胞菌(Pseudomonas aeruginosa);肺表面活性物质相关蛋白质A(Pulmonary Surfactant-Associated Protein A);痰(Sputum);底物特异性(Substrate Specificity)
DOI
10.1016/j.biocel.2013.05.018
PMID
23707200
发布时间
2021-10-21
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