换一批
换一批Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges.
第一单位：
Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
作者：
关键词
(1)H NMR(13)C NMR1 dimensional nuclear magnetic resonance1D NMR2 dimensional nuclear magnetic resonance2D NMRAnalytical techniquesCARTCE-MSCIDCNLSCOSYChallengesD-PLSDADDCBIDEPTDOSY–NMRDesigner analoguesEDESIEUEuropean UnionFT-ICR-MSFT-IRFTIR-ATRFourier transform ion cyclotron resonance-mass spectrometryFourier transformed infraredFourier transformed infrared attenuated total reflectanceGC–MSHMBCHMQCHPLCHPLC-DCBI–MS/MSHPTLCHRMSHSAHealth Sciences Authority SingaporeIDAIMSLC–ESI-MS(n)LC–FT-ICR-MSLC–LTQ Orbitrap XL FTMSLC–MSLC–TIS-MSLC–TOF-MSLC–q-TOF-MS/MSMDMAMRMMSMS(n)MS/MSNDANIRNMRNOENOESYNew Drug ApplicationPCAPDE-5PDE-5 inhibitorsPISPPPRECSIMSIMCASRMSVMScreening for adulterantsTHMPDTISTLCTOFTQ-LITTraditional Herbal Medicinal Products DirectiveUHPLCUSFDAUVUnited States Food and Drug AdministrationX-ray diffractionX-ray fluorescenceXRDXRFcapillary electrophoresis–mass spectrometrycarbon-13-nuclear magnetic resonanceclassification and regression treescollision induced dissociationconstant neutral loss scancorrelation spectroscopydesorption corona beam ionizationdiffusion ordered spectroscopy–nuclear magnetic resonancediode array detectordiscriminant partial least squaresdistortionless enhancement by polarization transferelectrospray ionizationerectile dysfunctiongas chromatography–mass spectrometryheteronuclear multiple-bond correlation spectroscopyheteronuclear multiple-quantum correlation spectroscopyhigh performance liquid chromatographyhigh performance liquid chromatography-desorption corona beam ionization–tandem mass spectrometryhigh performance thin layer chromatographyhigh resolution mass spectrometryinformation dependent acquisitionion mobility spectroscopyliquid chromatography mass-spectrometryliquid chromatography-Fourier transform ion cyclotron resonance-mass spectrometryliquid chromatography–electrospray ionization-tandem mass spectrometerliquid chromatography–linear ion orbitrap XL Fourier transform mass spectrometryliquid chromatography–quadrupole-time-of-flight-tandem mass spectrometryliquid chromatography–time of flight-mass spectrometryliquid chromatography–turbo ion spray mass spectrometrymass spectrometrymethylenedioxymethamphetaminemulti-stage mass spectrometrymultiple reaction monitoringnear infrarednuclear Overhauser effectnuclear Overhauser effect spectroscopynuclear magnetic resonancephosphodiesterase type 5 enzymeprecursor ion scanningprincipal component analysisproduct ion scanningprojection pursuitproton nuclear magnetic resonanceselected ion monitoringselected reaction monitoringsoft independent modelling by class analogysupport vector machinestandem mass spectrometrythin layer chromatographytime of flighttriple quadruple linear ion trapturbo ion sprayultra high performance liquid chromatographyultraviolet
主题词
咔啉类(Carbolines);化学技术, 分析(Chemistry Techniques, Analytical);药物污染(Drug Contamination);人类(Humans);咪唑类(Imidazoles);药用制剂(Pharmaceutical Preparations);磷酸二酯酶5抑制剂(Phosphodiesterase 5 Inhibitors);哌嗪类(Piperazines);植物制剂(Plant Preparations);嘌呤类(Purines);砜类(Sulfones);三嗪类(Triazines)
DOI
10.1016/j.jpba.2013.04.037
PMID
23721687
发布时间
2017-06-01
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