Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action.
第一作者:
Michael M,Swartz
第一单位:
Western Michigan University, Department of Biological Sciences, Kalamazoo, MI 49008, USA.
作者:
关键词
(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1methyl-indole-3-carboxylate4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride5-HT(3)AChAEBSFANOVACNSEDTAEGTAELISAExcitotoxicityFBSGluRsIgGIgMMAPKMLAN-methyl-d-aspartateNGFNMDANeuroprotectionPBSPMSFPigRGCRetinaRetinal ganglion cellsSDSTEAThyTropisetronacetylcholinealpha7 nicotinic acetylcholine receptoranalysis-of-variancecentral nervous systemenzyme-linked immunosorbent assayethylene glycol tetraacetic acidethylenediaminetetraacetic acidfetal bovine serumglutamate receptorsglycoprotein originally identified in thymus glandimmunoglobulin Gimmunoglobulin Mmethyllycaconitinemitogen activated protein kinasenAChRnerve growth factornicotinic acetylcholine receptorphenylmethylsulfonyl fluoridephosphate buffered salineretinal ganglion cellserotoninsodium dodecyl sulfatetetraethylammonium chloridetropisetronα7 nAChR
主题词
乌头碱(Aconitine);动物(Animals);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);谷氨酸(Glutamic Acid);吲哚类(Indoles);神经保护药(Neuroprotective Agents);烟碱激动剂(Nicotinic Agonists);烟碱拮抗剂(Nicotinic Antagonists);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);视网膜神经节细胞(Retinal Ganglion Cells);信号传导(Signal Transduction);猪(Swine);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)
DOI
10.1016/j.neuropharm.2013.05.020
PMID
23727438
发布时间
2021-10-21
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Neuropharmacology
111-21页
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