A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.-论文-万方医学网

作者： Andrea,Lunardi ^[1] ; Ugo,Ala ; Mirjam T,Epping ; Leonardo,Salmena ; John G,Clohessy ; Kaitlyn A,Webster ; Guocan,Wang ; Roberta,Mazzucchelli ; Maristella,Bianconi ; Edward C,Stack ; Rosina,Lis ; Akash,Patnaik ; Lewis C,Cantley ; Glenn,Bubley ; Carlos,Cordon-Cardo ; William L,Gerald ; Rodolfo,Montironi ; Sabina,Signoretti ; Massimo,Loda ; Caterina,Nardella ; Pier Paolo,Pandolfi

作者单位： Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. ^[1]

主题词雄激素拮抗药(Androgen Antagonists);雄激素类(Androgens);动物(Animals);抗肿瘤药(Antineoplastic Agents);苯甲酰胺类(Benzamides);细胞系, 肿瘤(Cell Line, Tumor);药物评价, 临床前(Drug Evaluation, Preclinical);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);模型, 生物学(Models, Biological);腈类(Nitriles);睾丸切除术(Orchiectomy);PTEN磷酸水解酶(PTEN Phosphohydrolase);苯硫乙内酰脲(Phenylthiohydantoin);前列腺肿瘤(Prostatic Neoplasms);信号传导(Signal Transduction);治疗, 临床研究性(Therapies, Investigational);治疗失败(Treatment Failure)

DOI 10.1038/ng.2650

PMID 23727860

发布时间 2021-12-03

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A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Nature genetics

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A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Nature genetics

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Nature genetics

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