换一批
换一批The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome.
作者：
主题词
淀粉样β蛋白前体(Amyloid beta-Protein Precursor);动物(Animals);星形细胞(Astrocytes);细胞分化(Cell Differentiation);细胞谱系(Cell Lineage);细胞形状(Cell Shape);疾病模型, 动物(Disease Models, Animal);唐氏综合征(Down Syndrome);女(雌)性(Female);基因沉默(Gene Silencing);猬蛋白质类(Hedgehog Proteins);海马(Hippocampus);人类(Humans);白细胞介素6(Interleukin-6);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);模型, 生物学(Models, Biological);神经干细胞(Neural Stem Cells);神经突(Neurites);神经发生(Neurogenesis);蛋白质结构, 三级(Protein Structure, Tertiary);受体, 细胞表面(Receptors, Cell Surface);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);三体性(Trisomy)
DOI
10.1074/jbc.M113.451088
PMID
23740250
发布时间
2021-10-21
- 浏览34
The Journal of biological chemistry
20817-20829页
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