换一批Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.
第一作者：
Elise,Morice
第一单位：
Centre de Neurosciences Paris-Sud, CNRS, Orsay, France.
作者：
关键词
90-kDa ribosomal S6 kinaseAMPArCLSCREBCSCoffin–LowryCoffin–Lowry syndromeConditioned stimulusEMEPSCERKElectron microscopyExcitatory postsynaptic currentsExtracellular signal-regulated kinaseField excitatory postsynaptic potentialGluRGlutamate receptorHippocampusIEGISIITIImmediate early geneIntellectual disabilityInter-stimulus intervalInter-trial intervalLTPLong-term potentiationMPPMSBMSK1/2Medial perforant pathMental retardationMetabotropic glutamate receptorMitogen stress-activated kinase 1 and 2Multiple spine boutonN-methyl-d-aspartate receptorNMDArPPFPPIPSDPTPPaired-pulse facilitationPaired-pulse inhibitionPost-tetanic potentiationPostsynaptic densityRSKReconsolidationSTPShort-term potentiationSynaptic morphologySynaptic plasticityTrace fear conditioningTranscription factorsUSUnconditioned stimulusWTWild-typecAMP-response element binding proteinfEPSPmGluRα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
医学主题词
动物(Animals);Coffin-Lowry综合征(Coffin-Lowry Syndrome);提示(Cues);齿状回(Dentate Gyrus);疾病模型, 动物(Disease Models, Animal);电刺激(Electric Stimulation);兴奋性突触后电位(Excitatory Postsynaptic Potentials);恐惧(Fear);凝固反应, 木僵状(Freezing Reaction, Cataleptic);记忆障碍(Memory Disorders);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);显微镜检查, 电子, 透射(Microscopy, Electron, Transmission);突变(Mutation);N-甲基天冬氨酸(N-Methylaspartate);神经组织蛋白质类(Nerve Tissue Proteins);核糖体蛋白质S6激酶类, 90-kDa(Ribosomal Protein S6 Kinases, 90-kDa);突触(Synapses);突触传递(Synaptic Transmission);α-氨基-3-羟基-5-甲基-4-异唑丙酸(alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
DOI
10.1016/j.nbd.2013.05.016
PMID
23742761
发布时间
2019-12-10
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Neurobiology of disease
156-68页
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