Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.
第一作者:
Takayo,Takemura
第一单位:
Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Osaka, Japan.
作者:
关键词
ALPALTBDLBile duct ligationEGFH&EHB-EGFHSCsHeparin-binding EGF-like growth factorHepatic stellate cellsKOLiver fibrosisRT-PCRT.BilTGF-βTNF-αTransforming growth factor-βWTalanine aminotransferasealkaline phosphatasebile duct ligationepidermal growth factorhematoxylin and eosinheparin-binding EGF-like growth factorhepatic stellate cellsknockoutpoly I:Cpolyinosinic:polycytidylic acidreverse-transcription polymerase chain reactiontotal bilirubintransforming growth factor-βtumor necrosis factor-αwild type
主题词
动物(Animals);胆管(Bile Ducts);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);肝硬化(Liver Cirrhosis);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout)
DOI
10.1016/j.bbrc.2013.05.097
PMID
23743191
发布时间
2022-03-10
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