换一批Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D₂-receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D₂-receptor occupancy.
第一作者：
Eef,Hoeben
第一单位：
Model Based Drug Development, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340, Beerse, Belgium, ehoeben@its.jnj.com.
作者：
医学主题词
成年人(Adult);老年人(Aged);抗精神病药(Antipsychotic Agents);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);模型, 生物学(Models, Biological);哌啶类(Piperidines);哒嗪类(Pyridazines);受体, 多巴胺D2(Receptors, Dopamine D2);精神分裂症(Schizophrenia);青年人(Young Adult)
DOI
10.1007/s40262-013-0084-3
PMID
23754735
发布时间
2021-10-21
- 浏览28
Clinical pharmacokinetics
1005-15页
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