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Mutational heterogeneity in cancer and the search for new cancer-associated genes.

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第一作者： Michael S,Lawrence

第一单位： The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.

作者： Michael S,Lawrence ^[1] ; Petar,Stojanov ^[2] ; Paz,Polak ^[3] ; Gregory V,Kryukov ^[3] ; Kristian,Cibulskis ^[1] ; Andrey,Sivachenko ^[1] ; Scott L,Carter ^[1] ; Chip,Stewart ^[1] ; Craig H,Mermel ^[4] ; Steven A,Roberts ^[5] ; Adam,Kiezun ^[1] ; Peter S,Hammerman ^[2] ; Aaron,McKenna ^[6] ; Yotam,Drier ^[7] ; Lihua,Zou ^[1] ; Alex H,Ramos ^[1] ; Trevor J,Pugh ^[8] ; Nicolas,Stransky ^[1] ; Elena,Helman ^[9] ; Jaegil,Kim ^[1] ; Carrie,Sougnez ^[1] ; Lauren,Ambrogio ^[1] ; Elizabeth,Nickerson ^[1] ; Erica,Shefler ^[1] ; Maria L,Cortés ^[1] ; Daniel,Auclair ^[1] ; Gordon,Saksena ^[1] ; Douglas,Voet ^[1] ; Michael,Noble ^[1] ; Daniel,DiCara ^[1] ; Pei,Lin ^[1] ; Lee,Lichtenstein ^[1] ; David I,Heiman ^[1] ; Timothy,Fennell ^[1] ; Marcin,Imielinski ^[4] ; Bryan,Hernandez ^[1] ; Eran,Hodis ^[2] ; Sylvan,Baca ^[2] ; Austin M,Dulak ^[2] ; Jens,Lohr ^[2] ; Dan-Avi,Landau ^[10] ; Catherine J,Wu ^[11] ; Jorge,Melendez-Zajgla ^[12] ; Alfredo,Hidalgo-Miranda ^[12] ; Amnon,Koren ^[13] ; Steven A,McCarroll ^[13] ; Jaume,Mora ^[14] ; Brian,Crompton ^[15] ; Robert,Onofrio ^[1] ; Melissa,Parkin ^[1] ; Wendy,Winckler ^[1] ; Kristin,Ardlie ^[1] ; Stacey B,Gabriel ^[1] ; Charles W M,Roberts ^[16] ; Jaclyn A,Biegel ^[17] ; Kimberly,Stegmaier ^[18] ; Adam J,Bass ^[8] ; Levi A,Garraway ^[8] ; Matthew,Meyerson ^[8] ; Todd R,Golub ^[19] ; Dmitry A,Gordenin ^[5] ; Shamil,Sunyaev ^[3] ; Eric S,Lander ^[20] ; Gad,Getz ^[4]

作者单位： The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA. ^[1] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Dana-Farber Cancer Institute, Boston, MA, 02215, USA. ^[2] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Harvard Medical School, Boston, MA, 02115, USA.;Brigham and Women's Hospital, Boston, MA, 02115, USA. ^[3] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Massachusetts General Hospital, Boston, MA, 02114, USA. ^[4] Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, NC 27709, USA. ^[5] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Genome Sciences, University of Washington, Seattle, WA 98195. ^[6] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Harvard Medical School, Boston, MA, 02115, USA.;Massachusetts General Hospital, Boston, MA, 02114, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA.;Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, 76100, Israel. ^[7] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Dana-Farber Cancer Institute, Boston, MA, 02215, USA.;Harvard Medical School, Boston, MA, 02115, USA. ^[8] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. ^[9] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Dana-Farber Cancer Institute, Boston, MA, 02215, USA.;Yale Cancer Center, Department of Hematology, New Haven, CT. ^[10] Dana-Farber Cancer Institute, Boston, MA, 02215, USA.;Harvard Medical School, Boston, MA, 02115, USA. ^[11] Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico. ^[12] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Harvard Medical School, Boston, MA, 02115, USA. ^[13] Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain. ^[14] Dana-Farber Cancer Institute, Boston, MA, 02215, USA.;Boston Children's Hospital, Boston, MA, 02115, USA. ^[15] Dana-Farber Cancer Institute, Boston, MA, 02215, USA.;Harvard Medical School, Boston, MA, 02115, USA.;Boston Children's Hospital, Boston, MA, 02115, USA. ^[16] Children's Hospital, Philadelphia, PA, 19104, USA. ^[17] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Dana-Farber Cancer Institute, Boston, MA, 02215, USA.;Boston Children's Hospital, Boston, MA, 02115, USA. ^[18] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Dana-Farber Cancer Institute, Boston, MA, 02215, USA.;Harvard Medical School, Boston, MA, 02115, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA. ^[19] The Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA.;Harvard Medical School, Boston, MA, 02115, USA.;Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. ^[20]