换一批A water-soluble selenoxide reagent as a useful probe for the reactivity and folding of polythiol peptides.
第一作者：
Kenta,Arai
第一单位：
Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa 259-1292, Japan.
作者：
关键词
1S,?2S,?3S,?and 4S, ensembles of SS intermediates with one, two, three, and four SS bonds, respectively1S°,?2S°,?and 3S°, ensembles of SS intermediates of CX-397 with one, two, and three kinetically formed SS bonds, respectively4-Dihydroxyselenolane oxideAEMTS, 2-aminoethyl methanethiosulfonateCD, circular dichroismCX-397, recombinant hirudin variant CX-397DHSox, trans-3,4-dihydroxyselenolane oxideDHSred, reduced DHSoxDTTox, oxidized dithiothreitolDTTred, dl-dithiothreitolDisulfideESI, electron spray ionizationGSSG, oxidized glutathioneGdn-HCl, guanidine hydrochlorideHPLC, high-performance liquid chromatographyHV-1, recombinant hirudin variant-1HV-3, recombinant hirudin variant-3Ins-A, insulin A-chainIns-B, insulin B-chainN, native proteinNHE, normal hydrogen electrodeOxidative foldingR, reduced polypeptideRNase A, ribonuclease ARedox potentialRlx-A, relaxin A-chainR°, reduced CX-397 at acidic conditionsSH, thiolSS, disulfideSeSe, diselenideS?, thiolateTFA, trifluoroacetic acidTris, tris(hydroxymethyl)aminomethane.pI, isoelectric pointtrans-3
DOI
10.1016/j.fob.2012.12.004
PMID
23772375
发布时间
2021-10-21
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FEBS open bio
55-64页
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