Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease.
作者:
关键词
17β-estradiol3,4-dihydroxyphenylacetic acid6-OHDA6-hydroxydopamineAIIAT1AT2AngiotensinAngiotensin IIAngiotensin type-1 receptorAngiotensin type-2 receptorDADOPACDopamineE2ERTGenderHPLCHigh performance liquid chromatographyMenopauseNeuroinflammationNeuroprotectionOvariectomizedOvxPDParkinson's diseaseRASROCKRT-PCRReal time polymerase chain reactionRenin–angiotensin system systemRhoRho-associated kinaseSNcSubstantia nigra compactaTHTH-immunoreactivityTH-irTyrosine hydroxylaseWBWestern blotestrogen replacement therapy
主题词
酰胺类(Amides);血管紧张素Ⅱ1型受体拮抗剂(Angiotensin II Type 1 Receptor Blockers);动物(Animals);苯咪唑类(Benzimidazoles);联苯化合物(Biphenyl Compounds);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);雌二醇(Estradiol);女(雌)性(Female);人类(Humans);MPTP中毒(MPTP Poisoning);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);运动活动(Motor Activity);神经保护药(Neuroprotective Agents);卵巢切除术(Ovariectomy);吡啶类(Pyridines);受体, 血管紧张素, 1型(Receptor, Angiotensin, Type 1);四唑类(Tetrazoles);酪氨酸单氧化酶(Tyrosine 3-Monooxygenase);rho相关激酶类(rho-Associated Kinases)
DOI
10.1016/j.nbd.2013.06.004
PMID
23774254
发布时间
2022-11-15
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Neurobiology of disease
209-19页
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