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首页> Free radical biology & medicine> Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study.

Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study.

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作者： Ada,Fiorini ^[1] ; Rukhsana,Sultana ^[2] ; Sarah,Förster ^[3] ; Marzia,Perluigi ^[4] ; Giovanna,Cenini ^[2] ; Chiara,Cini ^[4] ; Jian,Cai ^[5] ; Jon B,Klein ^[5] ; Susan A,Farr ^[6] ; Michael L,Niehoff ^[6] ; John E,Morley ^[6] ; Vijaya B,Kumar ^[6] ; D Allan,Butterfield ^[7]

作者单位： Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy; Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA. ^[1] Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA. ^[2] Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA; Department of Biochemistry, Institute of Animal Sciences, University of Bonn, Bonn, Germany. ^[3] Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy. ^[4] Department of Nephrology and Proteomics Center, University of Louisville, Louisville, KY 40292, USA. ^[5] Division of Geriatric Medicine Saint Louis University School of Medicine, St. Louis, MO, USA; VA Medical Center, St. Louis, MO, USA. ^[6] Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA. Electronic address: dabcns@uky.edu. ^[7]

关键词 5-bromo-4-chloro-3-indolyl phosphate/nitrotetrazolium blue chloride AATC AD AO APP Alzheimer's disease Amyloid precursor protein Amyloid β-peptide Aβ BCIP/NBT CRMP-1 CRMP-2 ES1 ES1 protein homolog FAD IDH3A, isocitrate dehydrogenase subunit alpha L-lactate dehydrogenase LDH M1/M2 KPYM MCI NAD NFT NSF PDHA1 and PDH PS-1 PS-2 SAM SNAPs Senescence accelerated mouse TPI V-ATPase amyloid precursor protein amyloid β-peptide antisense oligonucleotide aspartate aminotransferase dihydropyrimidinase-related protein 1 dihydropyrimidinase-related protein 2 familial Alzheimer's disease intracellular neurofibrillary tangles isocitrate dehydrogenase isoform M1 pyruvate kinase isozymes mild cognitive impairment presenilin-1 presenilin-2 pyruvate dehydrogenase E1 component subunit alpha and beta senescence accelerated mouse soluble N-ethylmaleimide-sensitive factor attachment proteins triosephosphate isomerase vacuolar-type H+-ATPase vesicle-fusing ATPase/vesicular-fusion protein NSF

主题词阿尔茨海默病(Alzheimer Disease);动物(Animals);印迹法, 蛋白质(Blotting, Western);疾病模型, 动物(Disease Models, Animal);电泳, 凝胶, 双向(Electrophoresis, Gel, Two-Dimensional);海马(Hippocampus);免疫沉淀法(Immunoprecipitation);质谱分析法(Mass Spectrometry);迷宫学习(Maze Learning);小鼠(Mice);寡核苷酸类, 反义(Oligonucleotides, Antisense);氧化性应激(Oxidative Stress);早老素1(Presenilin-1);蛋白质组学(Proteomics)

DOI 10.1016/j.freeradbiomed.2013.06.017

PMID 23777706

发布时间 2021-10-21

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