换一批Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation.
第一作者：
Ju Mei,Liu
第一单位：
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases, Ministry of Education, Hubei Provincial Key Laboratory of Neurological Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
作者：
关键词
2′-,7′-dichlorofluorescin diacetate3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideApoptosisBrain tumorCancer therapyDCFH-DADMEMDMSODulbecco’s modified Eagle’s mediumFBSFCMGBMGSHGliomaJNKMTTN-acetyl-l-cysteineNACOxidative stressPBSPIPLPiplartineROSc-jun N-terminal kinasedimethyl sulfoxidefetal bovine serumflow cytometryglioblastoma multiformeglutathionephosphate buffered salinepiperlonguminepropidium iodidereactive oxygen species
医学主题词
星形细胞(Astrocytes);细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);二恶茂烷类(Dioxolanes);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);酶激活(Enzyme Activation);胶质母细胞瘤(Glioblastoma);人类(Humans);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);活性氧(Reactive Oxygen Species);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)
DOI
10.1016/j.bbrc.2013.06.042
PMID
23796709
发布时间
2024-01-09
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