The inclusion complex of 4-hydroxynonenal with a polymeric derivative of β-cyclodextrin enhances the antitumoral efficacy of the aldehyde in several tumor cell lines and in a three-dimensional human melanoma model.

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第一作者： Stefania,Pizzimenti

第一单位： Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy. Electronic address: stefania.pizzimenti@unito.it.

作者： Stefania,Pizzimenti ^[1] ; Eric,Ciamporcero ^[2] ; Piergiorgio,Pettazzoni ^[2] ; Simona,Osella-Abate ^[3] ; Mauro,Novelli ^[3] ; Cristina,Toaldo ^[2] ; Miriam,Husse ^[2] ; Martina,Daga ^[2] ; Rosalba,Minelli ^[4] ; Agnese,Bisazza ^[4] ; Paolo,Ferruti ^[5] ; Elisabetta,Ranucci ^[5] ; Maria,Grazia Bernengo ^[3] ; Chiara,Dianzani ^[4] ; Fiorella,Biasi ^[2] ; Roberta,Cavalli ^[3] ; Giuseppina,Barrera ^[2]

作者单位： Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy. Electronic address: stefania.pizzimenti@unito.it. ^[1] Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy. ^[2] Section of Dermatology, Department of Medical Sciences, University of Turin, 10125 Turin, Italy. ^[3] Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy. ^[4] Department of Chemistry, University of Milan, Milano, Italy. ^[5]

关键词 4-Hydroxynonenal Free radicals Nanotechnology Three-dimensional human melanoma model Tumor cell lines β-Cyclodextrin–poly(4-acryloylmorpholine) conjugate