换一批A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity.
第一作者：
R,Castoldi
第一单位：
Pharma Research and Early Development (pRED), Roche Diagnostics GmbH, Penzberg, Germany.
作者：
医学主题词
动物(Animals);抗体, 双特异性(Antibodies, Bispecific);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);抗药性, 肿瘤(Drug Resistance, Neoplasm);肝细胞生长因子(Hepatocyte Growth Factor);人类(Humans);小鼠(Mice);表型(Phenotype);磷酰化(Phosphorylation);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);原癌基因蛋白质c-met(Proto-Oncogene Proteins c-met);信号传导(Signal Transduction);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1038/onc.2013.245
PMID
23812422
发布时间
2021-10-21
- 浏览9
Oncogene
5593-601页
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