换一批Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque.
第一作者：
Christin,Helmschrodt
第一单位：
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Germany; LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Germany. Electronic address: christin.helmschrodt@medizin.uni-leipzig.de.
作者：
关键词
-OHC-hydroxycholesterol5,6-α-EC5,6-α-epoxycholesterol5,6-β-EC5,6-β-epoxycholesterol7-KC7-ketocholesterol7-α- and 7-β-hydroxycholesterol7-α/β-OHCAPCIAtherosclerotic plaqueBHTCECEACIDCVCXPDPEPFast chromatographyFree oxysterolGC-MSHClHPLCHQCLCLC–MS/MSLLELLOQLODLQCMQCMRMNQCNa(2)SO(4)NaOHOxysterolPQCQCROSReactive oxygen speciesSPETandem mass spectrometryTriolatmospheric pressure chemical ionizationbutylated hydroxytoluenecarotid endarterectomycholestane-3β,5α,6β-triolcoefficient of variationcollision energycollision exit potentialcollision induced dissociationdeclustering potentialextensions potentialgas chromatography mass spectrometryhigh concentrated quality controlhigh-performance liquid chromatographyhydrochloric acidlimit of detectionliquid chromatographyliquid chromatography tandem mass spectrometryliquid–liquid extractionlow concentrated quality controllower level of quantificationmedium concentrated quality controlmultiple reacting monitoringnative quality controlpathological concentrated quality controlquality controlsreactive oxygen speciess/nsignal-to-noise ratiosodium hydroxidesodium sulfatesolid phase extraction
医学主题词
校准(Calibration);颈动脉(Carotid Arteries);胆固醇(Cholesterol);色谱法, 高压液相(Chromatography, High Pressure Liquid);色谱法, 液相(Chromatography, Liquid);女(雌)性(Female);人类(Humans);羟基胆甾醇类(Hydroxycholesterols);异构现象(Isomerism);酮胆甾醇类(Ketocholesterols);检测限(Limit of Detection);男(雄)性(Male);质谱分析法(Mass Spectrometry);中年人(Middle Aged);斑块, 动脉粥样硬化(Plaque, Atherosclerotic);活性氧(Reactive Oxygen Species);结果可重复性(Reproducibility of Results);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization);串联质谱法(Tandem Mass Spectrometry)
DOI
10.1016/j.cca.2013.06.022
PMID
23827692
发布时间
2013-10-11
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