Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.
作者:
关键词
AD-HIESAutosomal dominant hyper-IgE syndromeB-cell lymphomaBCLCTVCellTrace VioletCentral memory TEOMESEffector memory TEffector memory T cells expressing CD45RAEomesoderminIL-21IL-21 receptorIL-21RLCMVLymphocytic choriomeningitis virusPBPIDPeripheral bloodPrimary immunodeficiencySTATSTAT1STAT3Signal transducer and activator of transcriptionT(CM)T(EM)T(EMRA)T-cell receptorTCRdifferentiationhuman CD8(+) T cellsmemory
主题词
CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞分化(Cell Differentiation);人类(Humans);免疫记忆(Immunologic Memory);白细胞介素类(Interleukins);突变(Mutation);受体, 白细胞介素21(Receptors, Interleukin-21);STAT3转录因子(STAT3 Transcription Factor)
DOI
10.1016/j.jaci.2013.05.029
PMID
23830147
发布时间
2024-06-10
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