Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain.

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第一作者： László,Köles

第一单位： Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary.

作者： László,Köles ^[1] ; Pedro,Garção ; Zoltán S,Zádori ; Samira G,Ferreira ; Bárbara S,Pinheiro ; Carla S,da Silva-Santos ; Catherine,Ledent ; Attila,Köfalvi

作者单位： Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary. ^[1]

关键词 3Rs 4-AP 4-aminopyridine 7-, 14-, 29- and 60-day-old 7D, 14D, 29D, 60D ACEA ARC ARRIVE AUC American Radiolabeled Chemicals Animal Research: Reporting In Vivo Experiments BCA BSA CB(1) cannabinoid receptor CB(1)R DMSO DPM DTT Dopamine ECF EDTA EGTA FR Federation for Laboratory Animal Science Associations Felasa GABA Glutamate HEPES KHR KO Krebs-HEPES-Ringer LiGTP MAO B MgATP N-(2-hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)N-arachidonyl dopamine NADA NO PMSF PVDF RTX SDS SEM Serotonin Striatum TBS-T TRPV(1) vanilloid receptor TRPV(1)R and TRPV(4)R Tris Tris-buffered saline with Tween 20 WT aCSF arachidonyl-2′-chloroethylamide area-under-the-curve artificial cerebrospinal fluid bicinchoninic acid bovine serum albumin cannabinoid receptor type 1 dimethyl sulfoxide disintegration per minute dithiothreitol enhanced chemi-fluorescence ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid ethylenediaminetetraacetic acid fractional release knockout lithium guanozine triphosphate magnesium adenosine triphosphate monoamine oxidase B nitric oxide phenylmethanesulfonyl fluoride polyvinylidene difluoride replacement, reduction, refinement resiniferatoxin sEPSCs sodium dodecyl sulfate spontaneous excitatory postsynaptic currents standard error of the mean transient release potential receptor vanilloid type 4 tris(hydroxymethyl)aminomethane wild-type γ-aminobutyric acid

主题词动物(Animals);辣椒辣素(Capsaicin);纹状体(Corpus Striatum);多巴胺(Dopamine);兴奋性突触后电位(Excitatory Postsynaptic Potentials);女(雌)性(Female);谷氨酸(Glutamic Acid);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);突触前末梢(Presynaptic Terminals);放射性核素显像(Radionuclide Imaging);大鼠(Rats);大鼠, Wistar(Rats, Wistar);受体, 大麻酚, CB1(Receptor, Cannabinoid, CB1);血清素(Serotonin);TRPV阳离子通道(TRPV Cation Channels)

DOI 10.1016/j.brainresbull.2013.06.007

PMID 23831917

发布时间 2018-12-02

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Brain research bulletin

2013年97卷

126-35页

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Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain.

Brain research bulletin

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Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain.

Brain research bulletin

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Brain research bulletin

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