换一批Immobilized enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of bioengineered heparin.
第一作者：
Jian,Xiong
第一单位：
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu Province 225002, China.
作者：
关键词
2-O-sulfotransferase2OST3′-phosphoadenosine-5′-phosphate3′-phosphoadenosine-5′-phosphosulfate4-nitrophenyl sulfateAST-IVAryl sulfotransferase IVC(5)-epiC(5)-epimeraseESIHHCOSYHMQCHeparosanHpImmobilized enzymesLC/MSN-sulfo heparosan (NSH), N-sulfo, N-acetyl heparosanN-sulfo, N-acetyl, 2-O-sulfoheparinNACHpNMRNSNA2SHpNSNAHPAPPAPSPNPSarylsulfotransferase IVcGMPcurrent good manufacturing practiceselectrospray ionizationheparinheteronuclear multiple-quantum coherenceliquid chromatography/mass spectrometrynon-anticoagulant heparinnuclear magnetic resonanceproton–proton correlation spectroscopy
医学主题词
生物工程(Bioengineering);生物反应器(Bioreactors);碳水化合物差向异构酶类(Carbohydrate Epimerases);酶稳定性(Enzyme Stability);酶类, 固相(Enzymes, Immobilized);葡糖氨基聚糖类(Glycosaminoglycans);肝素(Heparin);磷酸腺苷磷酰硫酸(Phosphoadenosine Phosphosulfate);磺基转移酶类(Sulfotransferases)
DOI
10.1016/j.jbiotec.2013.06.018
PMID
23835156
发布时间
2024-03-23
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