换一批
换一批An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).
第一作者：
Manav,Korpal
第一单位：
1Oncology Disease Area, 2Department of Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge; and 3Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
作者：
主题词
雄激素拮抗药(Androgen Antagonists);雄激素受体拮抗剂(Androgen Receptor Antagonists);碱基序列(Base Sequence);苯甲酰胺类(Benzamides);细胞系, 肿瘤(Cell Line, Tumor);细胞周期蛋白依赖激酶4(Cyclin-Dependent Kinase 4);细胞周期蛋白依赖激酶6(Cyclin-Dependent Kinase 6);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);男(雄)性(Male);突变(Mutation);腈类(Nitriles);苯硫乙内酰脲(Phenylthiohydantoin);受体, 雄激素(Receptors, Androgen);序列分析, DNA(Sequence Analysis, DNA)
DOI
10.1158/2159-8290.CD-13-0142
PMID
23842682
发布时间
2022-03-17
- 浏览80
Cancer discovery
1030-43页
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