换一批Simplification of antitumoral phenanthroindolizidine alkaloids: short synthesis of cytotoxic indolizidinone and pyrrolidine analogs.
第一作者：
Javier,Miguélez
第一单位：
Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
作者：
关键词
(diacetoxyiodo)benzene80?W80?wattsAlkaloidArAr-MBocCNSCO(2)CMe(3)CytotoxicityDIBDMEMDMSODubelcco's modified Eagle mediumEtOAcFBSHRMSIndolizidineMHzNMRNOESYNuOTMSPhSARSequential processSynthetic methodologyTLCTMSTsVEHarylaryl-metalbrbroad signal (e.g. br s?=?broad singlet, br d?=?broad doublet, br b?=?broad band)central nervous systemdiastereomeric ratiodimethylsulfoxidedrethyl acetatefetal bovine serumhigh-resolution mass spectrometrymegahertzmelting pointmpnuclear Overhauser effect spectroscopynuclear magnetic resonancenucleophilepphenylprobabilitystructure–activity relationshipstetramethylsilanethin-layer chromatographytoluenesulfonyl (TsOH is toluenesulfonic acid)trimethylsilyloxyvehicle
主题词
生物碱类(Alkaloids);抗肿瘤药(Antineoplastic Agents);人类(Humans);吲哚嗪类(Indolizines);菲绕啉类(Phenanthrolines);吡咯烷类(Pyrrolidines)
DOI
10.1016/j.ejmech.2013.06.009
PMID
23845713
发布时间
2013-08-05
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