换一批
第一作者：
Claudia,Luckert
第一单位：
Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Straße 8-10, 10589 Berlin, Germany. Electronic address: claudia.luckert@bfr.bund.de.
作者：
关键词
(±)-anti-11,12-dihydroxy-13,14-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene(±)-anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene(±)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene(±)-trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene(±)-trans-3,4-dihydroxy-3,4-dihydrobenzo[c]phenanthrene(±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene3-MC3-methylcholanthreneAhRBaPBaPDBaPDEBcPBcPDBcPDECARCYPCYP3A4 inductionDBDDBalPDBalPDDBalPDEDNA-binding domainDRERGSTLBDPAHPPARγPXRPXR responsive element(s)PXREPolycyclic aromatic hydrocarbonsReporter gene assayUASUDP-glucuronosyltransferase(s)UGTXREMaryl hydrocarbon receptorbenzo[a]pyrenebenzo[c]phenanthreneconstitutive androstane receptorcytochrome P(450) monooxygenase(s)dNRdibenzo[a,l]pyrenedirect repeatdistal nuclear receptor-binding element(s)everted repeatglutathione S-transferase(s)ligand-binding domainperoxisome proliferator-activated receptor γpolycyclic aromatic hydrocarbon(s)pregnane X receptorqRT-PCRreal-time quantitative PCRupstream activation sequencexenobiotic-responsive enhancer module
医学主题词
苯并芘(Benzo(a)pyrene);苯并芘类(Benzopyrenes);致癌物, 环境(Carcinogens, Environmental);细胞存活(Cell Survival);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);二羟二氢苯并芘类(Dihydroxydihydrobenzopyrenes);酶诱导(Enzyme Induction);环氧化合物(Epoxy Compounds);基因, 报告(Genes, Reporter);HEK293细胞(HEK293 Cells);Hep G2细胞(Hep G2 Cells);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);配体(Ligands);启动区, 遗传(Promoter Regions, Genetic);受体, 类固醇(Receptors, Steroid);重组蛋白质类(Recombinant Proteins);信号传导(Signal Transduction);转录激活(Transcriptional Activation)
DOI
10.1016/j.toxlet.2013.06.243
PMID
23845848
发布时间
2018-12-11
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Toxicology letters
180-8页
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