换一批Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies.
第一作者：
Zhichun,Chen
第一单位：
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
作者：
关键词
(11)C-Pittsbergh compound(18)F-fluorodeoxyglucose8-OHG8-hydroxyguanosineADAD neuroimaging initiativeADNIADPAGEsAPOEAPPAPP C-terminal fragmentsAPP-CTFsATPAdvanced glycation endproductsAlzheimer's diseaseApoptosisAutophagyAβBBBCHEIsCMRgluCNSCOXCSFCerebral hypometabolismExcitotoxicityFDGG6PDHGLP-1GLUTGSK-3Glucagon-like peptide-1Glycogen synthase kinase 3IDEIGF-1IRIR substrate-1IRS-1Insulin resistanceKGDHCLTPMAPKMCIMMSEMRMitochondrial dysfunctionN-methyl-D-aspartic acid receptorNFTsNMDARNSAIDOxidative stressPDHCPETPI3KPKM2PPPPS1Peroxisome proliferator-activated receptorsPiBPositron emission tomographyRAGEROSSTZT1DMT2DMTCATDTDPTDPaseTGFTMPTMPaseTPKTauThiamineadenosine driphosphateadenosine triphosphateadvanced glycation end productsamyloid precursor proteinapolipoprotein Eblood brain barriercentral nervous systemcerebral metabolic rate of glucosecerebrospinal fluidcholinesterase inhibitorscytochrome c oxidaseglucagon-like peptide-1glucose transporterglucose-6-phosphate dehydrogenaseglycogen synthase kinase-3insulin receptorinsulin-degrading enzymeinsulin-like growth factor-1long term potentiationmTORmagnetic resonancemild cognitive impairmentmitogen-activated protein kinaseneurofibrillary tanglesnon-steroidal anti-inflammatory drugpentose phosphate pathwayphosphatidylinositide 3-kinasespositron emission tomographypresenilin-1pyruvate dehydrogenase complexpyruvate kinase isozyme type M2rCBFrCMRGlureactive oxygen speciesregional CMRGluregional cerebral blood flowstreptozotocinthe Mini-Mental State Examinationthe mammalian target of rapamycinthe receptor of AGEsthiamine deficiencythiamine diphosphatasethiamine diphosphatethiamine monophosphatasethiamine monophosphatethiamine pyrophosphokinasetransformation growth factortricarboxylic acidtype 1 diabetes mellitustype 2 diabetes mellitusα-ketoglutarate dehydrogenase complexβ-amyloidγ-PPARγ-peroxisome proliferator-actived receptor
医学主题词
阿尔茨海默病(Alzheimer Disease);脑化学(Brain Chemistry);糖尿病, 2型(Diabetes Mellitus, Type 2);葡萄糖(Glucose);葡萄糖转运蛋白质类, 易化性(Glucose Transport Proteins, Facilitative);人类(Humans);氧化性应激(Oxidative Stress);硫胺素(Thiamine)
DOI
10.1016/j.pneurobio.2013.06.004
PMID
23850509
发布时间
2022-03-11
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