换一批
换一批Depalmitoylation preferentially downregulates AMPA induced Ca2+ signaling and neurotoxicity in motor neurons.
作者：
关键词
2-BrP2-BromopalmitateAMPAAMPA receptorAmyotrophic lateral sclerosisCalcium signalingDepalmitoylationEMEMEagle′s minimal essential mediumExcitotoxicityHBSSHEPESHanks buffered salt salineMotor neuronN-2-hydroxyethyl piperazine-n-2-ethanesulphonic acidTARPsTransmembrane AMPA receptor regulatory proteinTransmembrane AMPA receptor regulatory proteinsα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
主题词
动物(Animals);钙(Calcium);钙信号(Calcium Signaling);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);胚胎, 哺乳动物(Embryo, Mammalian);降血糖药(Hypoglycemic Agents);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);脂化作用(Lipoylation);膜蛋白质类(Membrane Proteins);微管相关蛋白质类(Microtubule-Associated Proteins);运动神经元(Motor Neurons);棕榈酸盐类(Palmitates);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, AMPA(Receptors, AMPA);钠(Sodium);脊髓(Spinal Cord);α-氨基-3-羟基-5-甲基-4-异唑丙酸(alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
DOI
10.1016/j.brainres.2013.06.039
PMID
23850769
发布时间
2017-11-16
- 浏览82
Brain research
143-53页
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