换一批Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.
第一作者：
Jana,Mandíková
第一单位：
Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, Hradec Králové 500 05, Czech Republic.
作者：
关键词
1-methyl-4-phenylpyridiniumABCANPsATP-binding cassetteBCRPBCRP/ABCG2CNTsDMEMDulbecco's modified Eagle's mediumEMEMEagle's minimum essential mediumHeLaIC(50)MDCK IIMDR1MPP(+)MRPsMadin–Darby canine kidney II cell lineNephrotoxicityOATsOCTsPAHRFUSLCTransmembrane transportacyclic nucleoside phosphonatesbreast cancer resistance proteinconcentrative nucleoside transportershCNT2hCNT3hCNTshOAT1hOCT2human cervical epitheloid carcinoma cell linehuman concentrative nucleoside transporter 2human concentrative nucleoside transporter 3human organic anion transporter 1human organic cation transporter 2inhibitory concentration to reduce substrate accumulation to 50multidrug-resistance proteinsorganic anion transportersorganic cation transporterspara-aminohippuric acidrelative fluorescence unitssolute carrier family
医学主题词
动物(Animals);抗病毒药(Antiviral Agents);细胞存活(Cell Survival);狗(Dogs);人类(Humans);肾(Kidney);膜转运蛋白质类(Membrane Transport Proteins);嘌呤类(Purines)
DOI
10.1016/j.tox.2013.07.004
PMID
23856525
发布时间
2013-08-23
- 浏览113
Toxicology
135-46页
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