换一批Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.
第一作者：
G M Kamal B,Gunaherath
第一单位：
Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706, United States.
作者：
关键词
4-PP4-pyrrolidinopyridine4′,6-diamidino-2-phenylindoleBiological activityDAPIDCCEDCFITCHeat shock protein 90 (HSP90)N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimideNBT/BCIPNovobiocin analoguesPBAPFAPMSFStructure–activity relationshipSynthesisTNESTTBSa buffer solution containing tris, NaCl, EDTA, and SDSdicyclohexylcarbodiimidefluorescein isothiocyanateformaldehyde in phosphate buffered saline with bovine albuminnitro-blue tetrazolium chloride and 5-bromo-4-chloro-3′-indolyphosphate p-toluidine saltphenylmethylsulfonyl fluoridephosphate buffered saline with bovine albumintween 20 in tris buffered saline
医学主题词
抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);新生霉素(Novobiocin);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.bmc.2013.06.042
PMID
23859777
发布时间
2013-08-09
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